Herbimycin A

• Background :

  Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2). It is effective on Src, Yes, Fps, Ros, Abl and ErbB oncogene products (1-3) and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C (4). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.

• Description :

  Hsp90 inhibitor

• Product Name Alternative :

  [ (2R,3S,5S,6R,7S,8E,10S,11S,12E,14E) -2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1 (21),8,12,14,18-pentaen-10-yl] carbamate

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Heat Shock

• Purity :

  >98%

• Weight :

  0.001

• Format :

  Yellow Solid

• Solubility :

  Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)

• Molecular Formula :

  C30H42N2O9

• Molecular Weight :

  574.3

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Uehara Y., and Fukazawa H. (1991) Methods Enzymol. 201: 370. 2. Fukazawa H., et al. (1991) Biochem. Pharmacol. 42: 1661. 3. Satoh T., et al. (1992) J.Biol.Chem. 267: 2537. 4. Weiss R., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608.

• CAS Number :

  70563-58-5