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PNU-100766-d8

CAT: 0804-HY-10394S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10394S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PNU-100766-d8 is deuterated labeled Linezolid. Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics[1][2][3].
CAS Number
1032182-14-1
Product Name Alternative
PNU-100766-d8
UNSPSC
12352005
Hazard Statement
H372
Target
Antibiotic; Bacterial; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Purity
99.74
Solubility
10 mM in DMSO
Smiles
CC(NC[C@H]1CN(C2=CC=C(N3C([2H])([2H])C([2H])([2H])OC([2H])([2H])C3([2H])[2H])C(F)=C2)C(O1)=O)=O
Molecular Formula
C16H12D8FN3O4
Molecular Weight
345.40
Precautions
H372
References & Citations
[1]Clemett D, Markham A. Linezolid. Drugs. 2000 Apr;59 (4) :815-27; discussion 828.|[2]Chiappini E, Conti C, Galli L et al. Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic review. Clin Ther. 2010 Jan;32 (1) :66-88.|[3]Perry CM, Jarvis B. Linezolid: a review of its use in the management of serious gram-positive infections. Drugs. 2001;61 (4) :525-51.|[4]He MZ, Jiang YW, Cai C. Mechanisms and epidemiology of linezolid resistance in staphylococci.Zhonghua Jie He He Hu Xi Za Zhi. 2012 May;35 (5) :360-2.|[5]Karau MJ, Tilahun AY, Schmidt SM, Clark CR, Patel R, Rajagopalan G. Linezolid is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA class II Transgenic Mice. Antimicrob Agents Chemother. 2012 Jul 30.|[6]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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