Tapinarof

• Description :

  Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice[1].

• Product Name Alternative :

  WBI-1001; Benvitimod; GSK2894512

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Aryl Hydrocarbon Receptor

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Tapinarof.html

• Purity :

  99.95

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 100 mg/mL

• Smiles :

  OC1=C(C(C)C)C(O)=CC(/C=C/C2=CC=CC=C2)=C1

• Molecular Formula :

  C17H18O2

• Molecular Weight :

  254.32

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Smith SH, et al. Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans. J Invest Dermatol. 2017 Oct;137 (10) :2110-2119.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [79338-84-4]