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Api137

CAT: 0804-HY-P5723Size: 1 EachDry Ice: NoHazardous: No
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Description
Api137 is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain[1][2].
CAS Number
1428789-03-0
UNSPSC
12352209
Target
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/api137.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](/N=C(N(C)C)/N(C)C)CCCN)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N4[C@H](C(N5[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC6)=O)CC7=CNC=N7)=O)CCC5)=O)CCC4)=O)CCCNC(N)=N)=O)CCC3)=O)CCCNC(N)=N)=O)CCC2)=O)[C@H](CC)C)=O)CC8=CC=C(O)C=C8)=O)C(C)C)=O)CCC1)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O
Molecular Formula
C104H171N37O22
Molecular Weight
2291.71
References & Citations
[1]Florin T, et, al. An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome. Nat Struct Mol Biol. 2017 Sep;24 (9) :752-757.|[2]Graf M, et, al. Intracellular Antimicrobial Peptides Targeting the Protein Synthesis Machinery. Adv Exp Med Biol. 2019:1117:73-89.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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