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Tau Antibody

CAT: 0400-SPC-801DSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0400-SPC-801DSize:100 µg
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Background
Tau is a microtubule-associated protein predominantly found in neuronal axons, where it stabilizes microtubules and supports axonal transport. In the adult human brain, six isoforms of tau are expressed, generated by alternative splicing of the MAPT gene. These isoforms contain either three (3R) or four (4R) microtubule-binding repeat domains, with 2N4R (Tau-441) representing the full-length form. In healthy neurons, tau is tightly regulated. However, in neurodegenerative diseases known as tauopathies—including Alzheimer’s disease (AD), frontotemporal dementia, and progressive supranuclear palsy—tau becomes abnormally hyperphosphorylated. This modification reduces its affinity for microtubules, leading to the formation of insoluble neurofibrillary tangles (NFTs), a pathological hallmark of AD. Mutations in the MAPT gene, such as P301S (encoded by exon 10), impair tau’s ability to bind microtubules and promote aggregation. These mutations are commonly used in transgenic models to study tau-mediated neurotoxicity, synaptic dysfunction, and neuronal death. Tau pathology correlates strongly with cognitive decline in AD and is increasingly recognized as a driver of disease progression. As such, tau is a major focus of biomarker development and therapeutic targeting in neurodegenerative research.
Description
Rabbit Anti-Human Tau Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~45.8kda.
Product Name Alternative
Tau, TAU, TAU_HUMAN, MAPT, MAPTL, Microtubule-associated protein tau, Microtubule associated protein tau, Microtubule associated protein tau isoform 4, Neurofibrillary tangle protein, Paired helical filament tau, Paired helical filament-tau, PHF tau, PHF-tau, DDPAC, FTDP 17, G protein beta1/gamma2 subunit interacting factor 1, MSTD, Mtapt, MTBT1, MTBT2, PPND, PPP1R103, Protein phosphatase 1 regulatory subunit 103, RNPTAU, AI413597, AW045860, FLJ31424, MGC134287, MGC138549, MGC156665
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
4137
Swiss Prot
P10636
Cellular Locus
Cytoskeleton | Plasma Membrane | Cell Membrane | Peripheral Membrane Protein | Cytoplasmic Side | Cytosol | Axon | Microtubule | Microtubule Associated Complex | Tubulin Complex | Nucleus | Nuclear Periphery | Nuclear Speck | Axolemma Plasma Membrane | Axolemma | Cytoplasm | Cell Body | Cytoplasmic Ribonucleoprotein Granule | Dendrite | Growth Cone | Neurofibrillary Tangle | Neuronal Cell Body
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Tau 2NR4 P301S Fibril
Target
Tau
Clonality
Polyclonal
Conjugation
Unconjugated
Tissue Specificity
Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Type
Polyclonal
Applications
WB | ELISA | IHC
Validated Applications
WB, ELISA, IHC
Field of Research
Alzheimer's Disease | Axon Markers | Cell Markers | Cell Signaling | Cytoskeleton | Microtubules | MT Associated Proteins | Neurodegeneration | Neuron Markers | Neuroscience | Tangles & Tau
Purification
Protein A Purified
Detection Range
A 1:1000 dilution of SPC-801 was sufficient for detection of Tau in 10 μg of human SH-SY5Y cell lysate cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907) 3. Matsumoto, G. et al. (2018) . Int J Mol Sci. 19, 1497. 4. Goedert, M. and Spillantini, M. G. (2017) . Mol Brain. 10:18. 5. Guo, J. and Lee, M.Y. (2013) . FEBS Lett. 587 (6) : 717-723. 6. Alberici, A. et al. (2004) . J Neurol Neurosurg Psychiatry. 75:1607-1610.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~45.8kda.
Species
Human | Mouse
Location
Cytoskeleton | Plasma Membrane | Cell Membrane | Peripheral Membrane Protein | Cytoplasmic Side | Cytosol | Axon | Microtubule | Microtubule Associated Complex | Tubulin Complex | Nucleus | Nuclear Periphery | Nuclear Speck | Axolemma Plasma Membrane | Axolemma | Cytoplasm | Cell Body | Cytoplasmic Ribonucleoprotein Granule | Dendrite | Growth Cone | Neurofibrillary Tangle | Neuronal Cell Body
Immunogen Species
Human

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