LRP1 Antibody

CAT: 0400-SPC-785SSize: 12 µgDry Ice: NoHazardous: No
CAT#:0400-SPC-785SSize:12 µg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) is a multifunctional endocytic receptor involved in lipid metabolism, protease clearance, and cell signaling. In the brain, LRP1 regulates amyloid-beta clearance, synaptic plasticity, and blood-brain barrier integrity. Dysregulation of LRP1 is associated with Alzheimer’s disease, where impaired Aβ clearance contributes to plaque accumulation and neurotoxicity. LRP1 also modulates neuroinflammatory responses and interacts with key signaling pathways, including Wnt and TGF-β. Its broad functional repertoire and role in maintaining neural homeostasis make LRP1 a critical target in neurodegenerative disease research and therapeutic development.
Description
Rabbit Anti-Human LRP-1 Polyclonal
CAS Number
9007-83-4
Specifications
Detects 80 kDa. Band at 80 kDa is a membrane spanning subunit.
Product Name Alternative
LRP1, LRP-1, LRP-85, LRP-515, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1, CD91, LRPICD, APOER, APR
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
4035
Swiss Prot
Q07954
Accession Number
NP_002323.2
Cellular Locus
Cell Membrane | Single-Pass Type I Membrane Protein | Membrane | Coated Pit
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide from the N-terminal of Human Low-density lipoprotein receptor-related protein 1 (aa. 160-260)
Target
LRP-1
Clonality
Polyclonal
Conjugation
Unconjugated
Tissue Specificity
Most abundant in liver, brain and lung.
Type
Polyclonal
Applications
WB | IHC
Validated Applications
WB, IHC
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Cardiovascular System | Blood | Cancer | Apoptosis | Cancer Metabolism | Cardiovascular System | Atherosclerosis | Cancer | Cell Death
Purification
Peptide Affinity Purified
Detection Range
A 1:1000 dilution of SPC-785 was sufficient for detection of LRP-1 in 15 µg of mouse Brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000) ; IHC (1:50) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects 80 kDa. Band at 80 kDa is a membrane spanning subunit.
Species
Human | Mouse | Rat
Location
Cell Membrane | Single-Pass Type I Membrane Protein | Membrane | Coated Pit
Immunogen Species
Human

Alternative Products

Popular Products