LRP1 Antibody

• Background :

  LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) is a multifunctional endocytic receptor involved in lipid metabolism, protease clearance, and cell signaling. In the brain, LRP1 regulates amyloid-beta clearance, synaptic plasticity, and blood-brain barrier integrity. Dysregulation of LRP1 is associated with Alzheimer’s disease, where impaired Aβ clearance contributes to plaque accumulation and neurotoxicity. LRP1 also modulates neuroinflammatory responses and interacts with key signaling pathways, including Wnt and TGF-β. Its broad functional repertoire and role in maintaining neural homeostasis make LRP1 a critical target in neurodegenerative disease research and therapeutic development.

• Description :

  Rabbit Anti-Human LRP-1 Polyclonal

• Specifications :

  Detects 80 kDa. Band at 80 kDa is a membrane spanning subunit.

• Product Name Alternative :

  LRP1, LRP-1, LRP-85, LRP-515, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1, CD91, LRPICD, APOER, APR

• UNSPSC :

  12352203

• UN Code :

  Non-hazardous

• Hazard Statement :

  Non-hazardous

• Gene ID :

  4035

• Swiss Prot :

  Q07954

• Accession Number :

  NP_002323.2

• Cellular Locus :

  Cell Membrane | Single-Pass Type I Membrane Protein | Membrane | Coated Pit

• Host :

  Rabbit

• Species Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthetic peptide from the N-terminal of Human Low-density lipoprotein receptor-related protein 1 (aa. 160-260)

• Target :

  LRP-1

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Tissue Specificity :

  Most abundant in liver, brain and lung.

• Type :

  Polyclonal

• Applications :

  WB | IHC

• Validated Applications :

  WB, IHC

• Field of Research :

  Neuroscience | Neurodegeneration | Alzheimer's Disease | Cardiovascular System | Blood | Cancer | Apoptosis | Cancer Metabolism | Cardiovascular System | Atherosclerosis | Cancer | Cell Death

• Purification :

  Peptide Affinity Purified

• Detection Range :

  A 1:1000 dilution of SPC-785 was sufficient for detection of LRP-1 in 15 µg of mouse Brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

• Concentration :

  1 mg/ml

• Dilution :

  WB (1:1000) ; IHC (1:50) ; optimal dilutions for assays should be determined by the user.

• Weight :

  0.1

• Buffer :

  PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Shipping Conditions :

  Blue Ice or 4ºC

• Storage Conditions :

  -20ºC

• Specificity :

  Detects 80 kDa. Band at 80 kDa is a membrane spanning subunit.

• Species :

  Human | Mouse | Rat

• CAS Number :

  9007-83-4

• Location :

  Cell Membrane | Single-Pass Type I Membrane Protein | Membrane | Coated Pit

• Immunogen Species :

  Human