IGF-1 Antibody: FITC

• Background:

  Insulin-like Growth Factor 1 (IGF-1) is a peptide hormone structurally similar to insulin, playing a critical role in brain development, neuronal survival, and synaptic plasticity. Widely expressed in the central nervous system, IGF-1 exerts its effects through the IGF-1 receptor (IGF1R), activating downstream signaling pathways such as PI3K/Akt and MAPK/ERK—key regulators of cell growth, metabolism, and apoptosis. In neurodegenerative disease research, IGF-1 has emerged as a potent neuroprotective factor. It promotes neuronal survival by inhibiting apoptosis, enhancing mitochondrial function, and reducing oxidative stress. IGF-1 also supports neurogenesis and myelination, processes that are often impaired in disorders such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and Huntington’s disease. Reduced IGF-1 signaling has been associated with cognitive decline and increased vulnerability to neurodegeneration. Conversely, therapeutic delivery of IGF-1—via systemic administration, gene therapy, or intranasal routes—has shown promise in preclinical models by improving cognitive function, reducing protein aggregation, and restoring synaptic integrity. Given its multifaceted role in neural maintenance and repair, IGF-1 is a key target in the development of disease-modifying therapies for neurodegenerative conditions. Ongoing research continues to explore its potential in both early intervention and disease progression management.

• Description:

  Rabbit Anti-Human IGF-1 Polyclonal

• Specifications:

  Detects ~25 kDa.

• Product Name Alternative:

  IGF1, IGF-1, IGF-I, IGFI, IGF IA, IGF IB, IGF1A, IGFIA, IGF I, IGF 1, Insulin-like growth factor I, Insulin-like growth factor 1, Insulin like growth factor 1, Insulin like growth factor IA, Insulin like growth factor IB, Somatomedin C, Somatomedin-C, Somatomedia C, Mechano growth factor, MGF, IGF1_HUMAN, OTTHUMP00000195083, IBP1

• UNSPSC:

  12352203

• UN Code:

  Non-hazardous

• Hazard Statement:

  Non-hazardous

• Gene ID:

  3479

• Swiss Prot:

  P05019

• Accession Number:

  NP_000609.1

• Cellular Locus:

  Secreted

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide from the mid-protein of Human IGF-1

• Target:

  IGF-1

• Clonality:

  Polyclonal

• Conjugation:

  FITC

• Type:

  Polyclonal

• Applications:

  WB | ICC/IF | IHC

• Validated Applications:

  IHC, ICC/IF

• Field of Research:

  Cell Signaling | Growth Factors | Insulin and Insulin-like | Cancer

• Purification:

  Peptide Affinity Purified

• Detection Range:

  A 1:1000 dilution of SPC-699 was sufficient for detection of IGF-1 in 15 µg of mouse liver cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

• Concentration:

  1 mg/ml

• Dilution:

  WB (1:1000) ; ICC/IF (1:100) ; IHC (1:50) ; optimal dilutions for assays should be determined by the user.

• Weight:

  0.1

• Buffer:

  640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Shipping Conditions:

  Blue Ice or 4ºC

• Storage Conditions:

  Conjugated antibodies should be stored according to the product label

• Specificity:

  Detects ~25 kDa.

• Species:

  Human | Mouse

• CAS Number:

  9007-83-4

• Location:

  Secreted

• Immunogen Species:

  Human