GABARAP Antibody

Gamma-aminobutyric acid receptor-associated protein (GABARAP) is a multifunctional protein originally identified for its role in clustering and trafficking GABA-A receptors, the primary mediators of fast inhibitory neurotransmission in the brain. By anchoring these ligand-gated chloride channels to the cytoskeleton, GABARAP ensures proper receptor localization at synaptic membranes, thereby maintaining inhibitory synaptic strength and neuronal network stability. Beyond its role in receptor trafficking, GABARAP is now recognized as a critical component of the autophagy machinery. It belongs to the Atg8 family of proteins and participates in autophagosome formation, cargo recognition, and lysosomal degradation—processes essential for cellular homeostasis and neuroprotection. Dysregulation of GABARAP has been implicated in several neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease. Impaired GABARAP-mediated autophagy may lead to the accumulation of toxic protein aggregates and dysfunctional organelles, contributing to neuronal death and disease progression. Additionally, altered GABA-A receptor trafficking due to GABARAP dysfunction can disrupt inhibitory signaling, further exacerbating excitotoxicity and synaptic imbalance. Given its dual role in synaptic regulation and autophagy, GABARAP is emerging as a promising molecular target in neurodegeneration research. Understanding its mechanisms may offer new therapeutic strategies for restoring cellular homeostasis and preserving neural function in aging and disease.

Rabbit Anti-Human GABARAP Polyclonal

9007-83-4

Detects ~14-16kDa.

GABARAP, Gamma-aminobutyric acid receptor-associated protein, ATG8A, GABARAP A, MM46, GBRAP_HUMAN, FLC3B, HT004

12352203

Non-hazardous

Non-hazardous

11337

O95166

NP_009209.1

Endomembrane System | Cytoplasm | Cytoskeleton | Golgi Apparatus | Golgi Apparatus Membrane | Cytoplasmic Vesicle

Synthetic peptide from the N-terminal of human GABARAP

GABARAP

Unconjugated

Polyclonal

WB | ICC/IF

Neuroscience | Neurotransmission | Neurotransmitter Receptors | GABA Receptors | Cancer | Autophagy

Peptide Affinity Purified

A 1:1000 dilution of SPC-620 was sufficient for detection of GABARAP on mouse kidney lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

1 mg/ml

WB (1:1000) ; ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

0.012

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. "Entrez Gene: GABARAP GABA (A) receptor-associated protein".

Blue Ice or 4ºC

-20ºC

Detects ~14-16kDa.

Human | Mouse

Endomembrane System | Cytoplasm | Cytoskeleton | Golgi Apparatus | Golgi Apparatus Membrane | Cytoplasmic Vesicle