Amyloid Oligomers (A11) Antibody
CAT:
400-SPC-506S
Size:
12 µL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Amyloid Oligomers (A11) Antibody
- Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
- Description: Rabbit Anti-Human Amyloid Oligomers (A11) Polyclonal
- Specifications: Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
- Product Name Alternative: Neuroscience, Cell Signaling, Cardiovascular System, Blood, Neurodegeneration, Alzheimer's Disease, Amyloid
- CAS Number: 9007-83-4
- UNSPSC: 12352203
- Gene ID: 8666
- Swiss Prot: P05067
- Accession Number: NM_000484.2
- Cellular Locus: Membrane
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat, Eukaryote
- Immunogen: Synthetic molecular mimic of soluble human amyloid beta oligomers
- Target: Amyloid Oligomers (A11)
- Clonality: Polyclonal
- Conjugation: Unconjugated
- Validated Applications: WB, IHC, ICC/IF, IP, ELISA
- Purification: Protein A Purified
- Dilution: The suggested dilution for the current lot of SPC-506 in Western Blot and Dot Blot is 1:100; optimal dilutions for assays should be determined by the user.
- Weight: 0.012
- Buffer: PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
- Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- References & Citations: 1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.