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KDEL Antibody

CAT: 0400-SPC-109BSize: 200 µgDry Ice: NoHazardous: No
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CAT#:0400-SPC-109BSize:200 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The endoplasmic reticulum (ER) plays a central role in protein folding, quality control, and trafficking within eukaryotic cells. A key mechanism for retaining essential chaperones and folding enzymes within the ER involves the C-terminal KDEL sequence (Lys-Asp-Glu-Leu), a highly conserved ER retention motif. Proteins such as GRP78, GRP94, and protein disulfide isomerase (PDI) —critical for maintaining proteostasis—contain the KDEL motif, which ensures their retrieval from the Golgi apparatus back to the ER. This retention system is vital for sustaining ER function under both physiological and stress conditions. In the context of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and ALS, chronic ER stress and impaired protein homeostasis are hallmark features. The KDEL retrieval system is increasingly recognized as a key modulator of the unfolded protein response (UPR), a cellular defense mechanism activated by misfolded proteins. Dysregulation of KDEL-containing chaperones can exacerbate protein aggregation, neuronal dysfunction, and cell death. Moreover, experimental evidence suggests that enhancing KDEL-mediated retention can reduce aberrant protein secretion and improve ER stress resilience, offering potential therapeutic avenues. As such, the KDEL motif and its associated retrieval machinery are emerging as critical components in the study of neurodegeneration and cellular stress adaptation.
Description
Rabbit Anti-KDEL Polyclonal
CAS Number
9007-83-4
Specifications
Detects KDEL proteins, GRP94, Grp78, PDI and calreticulin. It may also see ERp57 and ERp29.
Product Name Alternative
KDEL, K-D-E-L, Lys-Asp-Glu-Leu, Lys-Asp-Glu-Leu (KDEL), Lysine-aspartic acid-glutamate-leucine
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Cellular Locus
Endoplasmic Reticulum
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
KDEL containing peptide immunogen
Target
KDEL
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | ICC/IF | IHC
Validated Applications
WB, ICC/IF, IHC
Field of Research
Cell Signaling | Tags and Cell Markers | Organelle Markers | Protein Trafficking | Chaperone Proteins
Purification
Protein A Purified
Detection Range
A 1:1000 dilution of SPC-109 was sufficient for detection of KDEL-containing proteins in 20 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-mouse IgG as the secondary.
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.
Weight
0.2
Buffer
PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Ozawa K., et al. (2008) Mol Pharmacol. 74:1610. 2. Austin R.C., et al. (2003) J Biol Chem. 278: 17438.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects KDEL proteins, GRP94, Grp78, PDI and calreticulin. It may also see ERp57 and ERp29.
Species
Human | Mouse | Rat
Location
Endoplasmic Reticulum

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