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GSK3182571

CAT: 0804-HY-12400-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12400-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK3182571 is a non-selective broad-spectrum kinase inhibitor with similar structure to CTx-0294885. GSK3182571 can induce changes in the thermostability of target proteins in cells. GSK3182571 can be used to explore the effects of drugs on kinase networks and off-target effects in leukemia cell models[1][2].
CAS Number
2135595-04-7
UNSPSC
12352005
Target
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk3182571.html
Purity
99.75
Solubility
1 M HCl : 50 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic; adjust pH to 4 with HCl)
Smiles
O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCN(CCCN)CC4)C=C3)=NC=C2Cl
Molecular Formula
C25H31ClN8O
Molecular Weight
495.02
References & Citations
[1]Mikhail M Savitski, et al. Tracking cancer drugs in living cells by thermal profiling of the proteome. Science. 2014 Oct 3;346 (6205) :1255784.|[2]Mateus A, et al. Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes. Proteome Sci. 2017 Jun 24;15:13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T35838-01GSK3182571

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