Repotrectinib

CAT: 0804-HY-103022-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103022-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Repotrectinib (TPX-0005) is a potent ROS1 (IC50=0.07 nM) and TRK (IC50=0.83/0.05/0.1 nM for TRKA/B/C) inhibitor. Repotrectinib potently inhibits WT ALK (IC50=1.01 nM) . Repotrectinib has anti-cancer activity[1][2].
CAS Number
[1802220-02-5]
Product Name Alternative
TPX-0005
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Anaplastic lymphoma kinase (ALK) ; ROS Kinase; Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TPX-0005.html
Purity
99.93
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1NC[C@H](C)OC2=CC=C(F)C=C2[C@@H](C)NC3=NC4=C1C=NN4C=C3
Molecular Formula
C18H18FN5O2
Molecular Weight
355.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Dayong Zhai, et al. Abstract 2132: The novel, rationally-designed, ALK/SRC inhibitor TPX-0005 overcomes multiple acquired resistance mechanisms to current ALK inhibitors. Cancer Research. July 2016|[2]Karachaliou N, et al. Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis. EBioMedicine. 2018 Mar;29:112-127.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
TrkA

Alternative Products

CatalogName
A4650-25Repotrectinib
A19850-1Repotrectinib 1mg
A19850-50Repotrectinib 50mg
A19850-5Repotrectinib 5mg
A19850-2Repotrectinib 2mg
A19850-10Repotrectinib 10mg
A19850-25Repotrectinib 25mg
A19850-100Repotrectinib 100mg
C13515-01Repotrectinib (TPX-0005)
A19850-10mM-DRepotrectinib 10mM * 1mL in DMSO

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