RUVBL1/2 ATPase-IN-1

RUVBL1/2 ATPase-IN-1

• CAS Number: 423128-55-6
• UNSPSC Description: RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ruvbl1-2-atpase-in-1.html
• Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(C1=C2N=C(C)C(CC3=CC=C(C)C=C3)=C(C)N2N=C1)N4CCN(C5=CC=CC(C(F)(F)F)=C5)CC4
• Molecular Weight: 507.55
• References & Citations: [1]Zhang G, et al. Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem. 2022;62:116726.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported