Ethyl Caffeate

• Description:

  Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  COX; NF-κB; NO Synthase; PGE synthase

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ethyl-caffeate.html

• Purity:

  99.34

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C(OCC)/C=C/C1=CC=C(O)C(O)=C1

• Molecular Formula:

  C11H12O4

• Molecular Weight:

  208.21

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Chiang YM, et al. Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. Br J Pharmacol. 2005 Oct;146 (3) :352-63.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  COX-2; iNOS; NF-κB

• CAS Number:

  [102-37-4]