IBS008738

CAT: 0804-HY-112821-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-112821-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model[1][2].

CAS Number

385425-03-6

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

YAP

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ibs008738.html

Purity

98.22

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=C(/N=C/N2CCOCC2)N=CN1C3=CC=C(C)C=C3)C4=CC=CC=C4

Molecular Formula

C22H22N4O2

Molecular Weight

374.44

Precautions

H315, H319, H335

References & Citations

[1]Yang Z, et al. Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. Mol Cell Biol. 2014;34 (9) :1607-1621.|[2]Zou R, et al. TAZ Activator Is Involved in IL-10-Mediated Muscle Responses in an Animal Model of Traumatic Brain Injury. Inflammation. 2017;40 (1) :100-105.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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