HIV-1 inhibitor-79

• UNSPSC Description:

  HIV-1 inhibitor-79 (Compound 3k) is an HIV inhibitor that exhibits significant inhibitory activity against HIV-1 and its common mutant strains (with IC50 values of 1.9, 1.9, 8.7, and 11 nM against HIV-1, K103, L100I, and E138K, respectively), and has low cytotoxicity and a high selectivity index (CC50 = 21.95 μM, SI = 11478). Additionally, HIV-1 inhibitor-79 also shows antiviral activity against HIV-2, with an EC50 value of 6.14 μM, and significantly inhibits the activity of HIV-1 reverse transcriptase (IC50 = 25 nM)[1].

• Target Antigen:

  HIV; Reverse Transcriptase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/hiv-1-inhibitor-79.html

• Smiles:

  CC1=CC(/C=C/C#N)=CC(C)=C1OC2=CC=NC(NC3=CN4C(C=C3)=NN=C4)=N2

• Molecular Weight:

  383.41

• References & Citations:

  [1]Dai J, et al. Discovery of novel fused-heterocycle-bearing diarypyrimidine derivatives as HIV-1 potent NNRTIs targeting tolerant region I for enhanced antiviral activity and resistance profile. Eur J Med Chem. 2025 Jan 5;281:117033.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported