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Tolfenamic Acid (Standard)

CAT: 0804-HY-B0335R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0335R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tolfenamic Acid (Standard) is the analytical standard of Tolfenamic Acid. This product is intended for research and analytical applications. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
CAS Number
13710-19-5
Product Name Alternative
GEA 6414 (Standard)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; Reference Standards
Type
Reference Standards
Related Pathways
Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/tolfenamic-acid-standard.html
Purity
99.97
Smiles
O=C(O)C1=CC=CC=C1NC2=C(C)C(Cl)=CC=C2
Molecular Formula
C14H12ClNO2
Molecular Weight
261.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Kay-Mugford P, et al. In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs. Am J Vet Res. 2000 Jul;61 (7) :802-10.|[2]Maliakal P, et al. Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats. Invest New Drugs. 2012 Jun;30 (3) :853-61.|[3]Sankpal UT, et al. Tolfenamic acid-induced alterations in genes and pathways in pancreatic cancer cells. Oncotarget. 2017 Feb 28;8 (9) :14593-14603
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

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