Multi-target kinase inhibitor 2

Multi-target kinase inhibitor 2

• UNSPSC Description: Multi-target kinase inhibitor 2 (compound 5K) is a multi-targeted kinase inhibitor, and exhibits activity against EGFR, Her2, VEGFR2, and CDK2 enzymes, with IC50 values ranging from 40 to 204 nM. Multi-target kinase inhibitor 2 shows cytotoxic effects were observed against HepG2, HeLa , MDA-MB-231 and MCF-7, with IC50 of 41, 57, 51 and 59 μM. Multi-target kinase inhibitor 2 induces cell cycle arrest and apoptosis in HepG2 cells.
• Target Antigen: CDK; EGFR; VEGFR
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/multi-target-kinase-inhibitor-2.html
• Solubility: DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(N/N=C/C1=CC(Cl)=C(Cl)C=C1)C2=CC=C(C=C2)NC3=NC=NC4=C3C=CN4
• Molecular Weight: 425.27
• References & Citations: [1]Alotaibi AA, et al. Discovery of New Pyrrolo[2,3-d]pyrimidine Derivatives as Potential Multi-Targeted Kinase Inhibitors and Apoptosis Inducers. Pharmaceuticals (Basel). 2023;16(9):1324. Published 2023 Sep 19.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported