Formamide-d1

• Description:

  Formamide-d1 is the deuterium labeled Formamide (HY-Y0842) . Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers.[1][2][3][4][5][6][7]

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Apoptosis; Biochemical Assay Reagents; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Cardiovascular Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  NC ([2H]) =O

• Molecular Formula:

  CH2DNO

• Molecular Weight:

  46.05

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]Kamineni VK, et al. Layer-by-layer nanoassembly of polyelectrolytes using formamide as the working medium. Langmuir. 2007;23 (14) :7423-7.|[2]Blake RD, et al. Thermodynamic effects of formamide on DNA stability. Nucleic Acids Res. 1996 Jun 1;24 (11) :2095-103.|[3]Costanzo G, et al. Formamide as the main building block in the origin of nucleic acids. BMC Evol Biol. 2007 Aug 16;7 Suppl 2 (Suppl 2) :S1.|[4]Brette F, et al. Validation of formamide as a detubulation agent in isolated rat cardiac cells. Am J Physiol Heart Circ Physiol. 2002 Oct;283 (4) :H1720-8.|[5]Frankfurt OS, Krishan A. Identification of apoptotic cells by formamide-induced dna denaturation in condensed chromatin. J Histochem Cytochem. 2001 Mar;49 (3) :369-78.|[6]Messier PE.Messier PE. Effects of formamide on neuroepithelial cells and on interkinetic nuclear migration in the chick embryo. J Embryol Exp Morphol. 1976 Feb;35 (1) :197-212.|[7]National Toxicology Program. Toxicology and carcinogenesis studies of formamide (Cas No. 75-12-7) in F344/N rats and B6C3F1 mice (gavage studies) . Natl Toxicol Program Tech Rep Ser. 2008 Jul; (541) :1-192.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  35692-88-7