Clomipramine-d3 (hydrochloride)

Clomipramine-d3 (hydrochloride)

• CAS Number: 1398065-86-5
• UNSPSC Description: Clomipramine-d3 (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].
• Target Antigen: Dopamine Receptor; Serotonin Transporter
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Purity: 99.98
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: ClC1=CC2=C(CCC3=C(N2CCCN(C)C([2H])([2H])[2H])C=CC=C3)C=C1.Cl
• Molecular Weight: 354.33
• References & Citations: [1] Owens, M.J., et al., Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther, 1997. 283(3): p. 1305-22.|[2]McTavish, D. and P. Benfield, Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs, 1990. 39(1): p. 136-53.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported