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Adoprazine

CAT: 0804-HY-14782-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14782-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine (SLV313) is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics[1].
CAS Number
222551-17-9
Product Name Alternative
SLV313
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Adoprazine.html
Concentration
10mM
Purity
98.60
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C2=CN=CC(CN3CCN(C4=C5OCCOC5=CC=C4)CC3)=C2)C=C1
Molecular Formula
C24H24FN3O2
Molecular Weight
405.46
References & Citations
[1]Andrew C McCreary, et al. SLV313 (1- (2,3-dihydro-benzo[1,4]dioxin-5-yl) -4- [5- (4-fluoro-phenyl) -pyridin-3-ylmethyl]-piperazine monohydrochloride) : a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology. 2007 Jan;32 (1) :78-94.|[2]Liesbeth A Bruins Slot, et al. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534 (1-3) :63-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
5-HT1 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; mLAG-3; MUC3

Alternative Products

CatalogName
BA5039-5Adoprazine
MBS386690-01Adoprazine (SLV313)
A11297-10Adoprazine 10mg
MBS5812317Adoprazine hydrochloride
A11297-5Adoprazine 5mg
A11297-50Adoprazine 50mg
A11297-25Adoprazine 25mg
A11297-1Adoprazine (SLV313) 1mg
A11297-100Adoprazine (SLV313) 100mg
A11297-10mM-DAdoprazine (SLV313) 10mM * 1mL in DMSO

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