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Neogrifolin

CAT: 0804-HY-N8387Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N8387Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Neogrifolin is an inhibitor of KRAS. Neogrifolin suppress KRAS expression in human colon cancer cells. Neogrifolin has anti-cell viability activity against HeLa, SW480 and HT29 cells wih IC50s of 24.3, 34.6, and 30.1 μM, respectively[1].
CAS Number
23665-96-5
UNSPSC
12352005
Target
Ras
Type
Natural Products
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/neogrifolin.html
Solubility
10 mM in DMSO
Smiles
OC1=CC(C)=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)C(O)=C1
Molecular Formula
C22H32O2
Molecular Weight
328.49
References & Citations
[1]Yaqoob A, et al. Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells. PLoS One. 2020 May 5;15 (5) :e0231948.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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