Products for Research Use Only
RegisterLogin

Triclosan

CAT: 0804-HY-B1119-01Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1119-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC) . Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models[1][2][3].
CAS Number
3380-34-5
UNSPSC
12352005
Hazard Statement
H315, H319, H410
Target
Antibiotic; Apoptosis; Bacterial; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Triclosan.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C) |Methanol : 100 mg/mL (ultrasonic)
Smiles
OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
Molecular Formula
C12H7Cl3O2
Molecular Weight
289.55
Precautions
H315, H319, H410
References & Citations
[1]R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274 (16) :11110-4.|[2]Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul) . 2016 Jan;24 (1) :99-107.|[3]Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13 (1) :136.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched

Related Products

CatalogName
HY-W130307Tricosane
HY-W130307R-01Tricosane (Standard)
HY-W130307STricosane-d48

Alternative Products

CatalogName
C4035-1000Triclosan

Popular Products