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T0467

CAT: 0804-HY-139308-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139308-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research[1].
CAS Number
859518-94-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Mitochondrial Metabolism; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/t0467.html
Purity
99.30
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
FC1=CC=C(CN2[C@H](CNCC2)C)C=C1C3=NC(NCCC4=CC(F)=CC(F)=C4)=NC=C3
Molecular Formula
C24H26F3N5
Molecular Weight
441.49
Precautions
H315, H319, H335
References & Citations
[1]Kahori Shiba-Fukushima, et al. A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling. iScience. 2020 May 22;23 (5) :101048.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA3697-10T0467

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