Hydroxyurea

• Description :

  Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity.

• Product Name Alternative :

  Hydroxycarbamide

• UNSPSC :

  12352211

• Hazard Statement :

  H340, H361

• Target :

  Apoptosis; Autophagy; DNA/RNA Synthesis; HIV; Orthopoxvirus

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hydroxyurea.html

• Purity :

  99.34

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(N)NO

• Molecular Formula :

  CH4N2O2

• Molecular Weight :

  76.05

• Precautions :

  H340, H361

• References & Citations :

  [1]Kovacic P, et al. Hydroxyurea (therapeutics and mechanism) : metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med Hypotheses. 2011 Jan;76 (1) :24-31.|[2]Watanapokasin Y, et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin E patients. Exp Hematol. 2005 Dec;33 (12) :1486-92.|[3]Lori F, et al. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun;30 Suppl 2:S193-7.|[4]Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95 (9) :1599-603.|[5]M B Slabaugh, et al. Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase. J Virol. 1986 Nov;60 (2) :506-14.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  HIV-1

• CAS Number :

  [127-07-1]