Hydroxyurea

CAT: 0804-HY-B0313-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0313-01Size:500 mg
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Description
Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity.
CAS Number
[127-07-1]
Product Name Alternative
Hydroxycarbamide
UNSPSC
12352211
Hazard Statement
H340, H361
Target
Apoptosis; Autophagy; DNA/RNA Synthesis; HIV; Orthopoxvirus
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hydroxyurea.html
Purity
99.34
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N)NO
Molecular Formula
CH4N2O2
Molecular Weight
76.05
Precautions
H340, H361
References & Citations
[1]Kovacic P, et al. Hydroxyurea (therapeutics and mechanism) : metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med Hypotheses. 2011 Jan;76 (1) :24-31.|[2]Watanapokasin Y, et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin E patients. Exp Hematol. 2005 Dec;33 (12) :1486-92.|[3]Lori F, et al. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun;30 Suppl 2:S193-7.|[4]Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95 (9) :1599-603.|[5]M B Slabaugh, et al. Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase. J Virol. 1986 Nov;60 (2) :506-14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1

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