Bupropion morpholinol

• Description :

  Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities[1][2][3].

• CAS Number :

  [357399-43-0]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Dopamine Transporter; nAChR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/bupropion-morpholinol.html

• Purity :

  99.66

• Solubility :

  Ethanol : 20 mg/mL (ultrasonic; warming)

• Smiles :

  OC1(C2=CC=CC(Cl)=C2)C(C)NC(C)(C)CO1

• Molecular Formula :

  C13H18ClNO2

• Molecular Weight :

  255.74

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Zhu AZX, et, al. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clin Pharmacol Ther. 2012 Dec;92 (6) :771-7.|[2]Damaj MI, et, al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66 (3) :675-82.|[3]Damaj MI, et, al. Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice. J Pharmacol Exp Ther. 2010 Sep 1;334 (3) :1087-95.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported