Bupropion morpholinol

• UNSPSC Description:

  Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities[1][2][3].

• Target Antigen:

  Dopamine Transporter; nAChR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bupropion-morpholinol.html

• Purity:

  99.66

• Solubility:

  Ethanol : 20 mg/mL (ultrasonic;warming)

• Smiles:

  OC1(C2=CC=CC(Cl)=C2)C(C)NC(C)(C)CO1

• Molecular Weight:

  255.74

• References & Citations:

  [1]Zhu AZX, et, al. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clin Pharmacol Ther. 2012 Dec;92(6):771-7.|[2]Damaj MI, et, al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66(3):675-82.|[3]Damaj MI, et, al. Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice. J Pharmacol Exp Ther. 2010 Sep 1;334(3):1087-95.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  357399-43-0