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Bupropion morpholinol

CAT: 0804-HY-12766Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12766Size:5 mg
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Description
Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities[1][2][3].
CAS Number
[357399-43-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Dopamine Transporter; nAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bupropion-morpholinol.html
Purity
99.66
Solubility
Ethanol : 20 mg/mL (ultrasonic; warming)
Smiles
OC1(C2=CC=CC(Cl)=C2)C(C)NC(C)(C)CO1
Molecular Formula
C13H18ClNO2
Molecular Weight
255.74
Precautions
H315, H319, H335
References & Citations
[1]Zhu AZX, et, al. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clin Pharmacol Ther. 2012 Dec;92 (6) :771-7.|[2]Damaj MI, et, al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66 (3) :675-82.|[3]Damaj MI, et, al. Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice. J Pharmacol Exp Ther. 2010 Sep 1;334 (3) :1087-95.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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