AIP-II

• Description :

  AIP-II is a macrocyclic peptide signaling molecule used for quorum sensing, which can be produced be Staphylococcus aureus. AIP-II binds to AgrC-II receptor, regulates the virulence gene expression in Staphylococcus aureus. AIP-II is an antagonist for AgrC-I receptor[1].

• CAS Number :

  [200010-31-7]

• UNSPSC :

  12352209

• Target :

  Bacterial

• Type :

  Peptides

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/aip-ii.html

• Purity :

  98.04

• Smiles :

  O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSC1=O)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC(CN)=O)=O)=O)=O)=O)CO)=O)CO)=O)CC(C)C)N[C@H]1CC2=CC=CC=C2

• Molecular Formula :

  C38H58N10O12S

• Molecular Weight :

  878.99

• References & Citations :

  [1]Tal-Gan Y, et al., Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus. J Am Chem Soc. 2013 Dec 11;135 (49) :18436-44.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported