Lasalocid

• Description:

  Lasalocid (Lasalocid-A) is an antibacterial and anticoccidial agent that can be used as feed additives. Lasalocid exhibits antitumor activity. Lasalocid is orally active[1][2][3].

• Product Name Alternative:

  Lasalocid-A; Ionophore X-537A; Antibiotic X-537A

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Antibiotic; Apoptosis; Autophagy; Bacterial; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Autophagy

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/Lasalocid.html

• Concentration:

  10mM

• Purity:

  98.49

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(O)C1=C(CC[C@@H](C)[C@H](O)[C@H](C)C([C@@H]([C@H]2O[C@@]([C@H]3CC[C@](O)(CC)[C@H](C)O3)(CC)C[C@@H]2C)CC)=O)C=CC(C)=C1O

• Molecular Formula:

  C34H54O8

• Molecular Weight:

  590.79

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Chen M, et al. Effect of monensin and lasalocid-sodium on the growth of methanogenic and rumen saccharolytic bacteria. Appl Environ Microbiol. 1979 Jul;38 (1) :72-7.|[2]Kim KY, et al., Lasalocid induces cytotoxic apoptosis and cytoprotective autophagy through reactive oxygen species in human prostate cancer PC-3 cells. Biomed Pharmacother. 2017 Apr;88:1016-1024.|[3]OZ HS, et al., Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis. Antimicrob Agents Chemother. 1997 Jan;41 (1) :191-2.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Citation 01:

  BioRxiv. 2023 Jun 25.|J Cancer. 2025 Jan 1;16 (3) :765-783.|Talanta. 2025 Apr 10:293:128128.|Langmuir. 2020 Mar 31;36 (12) :3184-3192.

• CAS Number:

  [25999-31-9]