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Tanaproget

CAT: 0804-HY-15606-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15606-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tanaproget is an orally effective, selective nonsteroidal progesterone receptor (PR) agonist targeting human PR with an IC50 of 1.7 nM. Tanaproget promotes the interaction between PR receptors and coactivators (such as SRC-1), thereby inhibiting the secretion of matrix metalloproteinases (MMP-3/MMP-7) and reducing endometrial tissue invasion and angiogenesis. Tanaproget can be used for contraception and endometriosis inhibition research[1][2][3].
CAS Number
304853-42-7
Product Name Alternative
NSP-989
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Progesterone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/tanaproget.html
Purity
99.73
Solubility
DMSO : ≥ 50 mg/mL
Smiles
N#CC1=CC=C(C2=CC=C(NC(OC3(C)C)=S)C3=C2)N1C
Molecular Formula
C16H15N3OS
Molecular Weight
297.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Bruner-Tran KL, et al. Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. J Clin Endocrin.|[2]Zhang Z, et al. Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget. J Biol Chem. 2005 Aug 5;280 (31) :28468-75.|[3]Bapst JL, et al. Pharmacokinetics and safety of tanaproget, a nonsteroidal progesterone receptor agonist, in healthy women. Contraception. 2006 Nov;74 (5) :414-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

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A3857-50Tanaproget
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A15256-5Tanaproget 5mg
A15256-10Tanaproget 10mg
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A15256-50Tanaproget 50mg
A15256-2Tanaproget 2mg
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