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Picoplatin

CAT: 0804-HY-131468-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131468-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA[1].
CAS Number
181630-15-9
Product Name Alternative
AMD473; ZD0473
UNSPSC
12352005
Hazard Statement
H290, H317, H334, H340, H350
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/picoplatin.html
Purity
98.5
Solubility
10 mM in DMSO
Smiles
[Cl-][Pt+2]([N]1=C(C)C=CC=C1)([NH3])[Cl-]
Molecular Formula
C6H10Cl2N2Pt
Molecular Weight
376.15
Precautions
H290, H317, H334, H340, H350
References & Citations
[1]J Holford, et al. In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473. Br J Cancer. 1998;77 (3) :366-73.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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FP65130-01Picoplatin
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A14108-25Picoplatin 25mg
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