ADAMTS-5-IN-2

• UNSPSC Description:

  ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2].

• Target Antigen:

  ADAMTS

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/adamts-5-in-2.html

• Smiles:

  O=C1NC2=C(C=C(CC)C=C2)C13SC(C4=CC=CC=C4)=NN3

• Molecular Weight:

  309.39

• References & Citations:

  [1]Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18(8):461-74.|[2]Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 2007, 17(20), 5630-5633.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  294648-66-1