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Buloxibutid

CAT: 0804-HY-100113-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100113-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Buloxibutid (AT2 receptor agonist C21) is a agentlike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively[1].
CAS Number
477775-14-7
Product Name Alternative
AT2 receptor agonist C21
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/buloxibutid.html
Purity
99.02
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(OCCCC)NS(=O)(C1=C(C2=CC=C(CN3C=CN=C3)C=C2)C=C(CC(C)C)S1)=O
Molecular Formula
C23H29N3O4S2
Molecular Weight
475.62
Precautions
H302, H312, H315, H319
References & Citations
[1]Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47 (24) :5995-6008.|[2]Schwengel K, Namsolleck P, Lucht K, et al. Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. J Mol Med (Berl) . 2016;94 (8) :957-966. |[3]Fatima N, Patel S, Hussain T. Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10. Front Pharmacol. 2021;12:600163.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
AT1 Receptor; AT2 Receptor

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