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NSAH

CAT: 0804-HY-114503-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-114503-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].
CAS Number
1099592-35-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsah.html
Concentration
10mM
Purity
98.45
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O
Molecular Formula
C18H14N2O3
Molecular Weight
306.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114 (31) :8241-8246.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-Hydroxy-1-naphthalaldehyde salicyloylhydrazone

structure given in first source

CAS Number1099592-35-4
PubChem CID135458654
IUPAC Name2-hydroxy-N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]benzamide
Molecular FormulaC18H14N2O3
Molecular Weight306.3
XLogP3.9
Topological Polar Surface Area81.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity440
SMILES
C1=CC=C2C(=C1)C=CC(=C2/C=N/NC(=O)C3=CC=CC=C3O)O
InChI
InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+
InChIKey
ZZSJOLDICPVVAV-YBFXNURJSA-N
Chemical Structure
2D Structure
2D structure of 2-Hydroxy-1-naphthalaldehyde salicyloylhydrazone
CAS: 1099592-35-4
CID: 135458654
Formula: C18H14N2O3
MW: 306.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.3
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass306.10044231
Monoisotopic Mass306.10044231
Topological Polar Surface Area81.9 Ų
Heavy Atom Count23
Formal Charge0
Complexity440
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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