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Dehydrocrenatidine

CAT: 0804-HY-N3710Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3710Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2].
CAS Number
65236-62-6
Product Name Alternative
Kumujian G; O-Methylpicrasidine I
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; JAK
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dehydrocrenatidine.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC2=C1NC3=C2C(OC)=CN=C3C=C
Molecular Formula
C15H14N2O2
Molecular Weight
254.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jing Zhang, et al. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 2015 Apr;87 (4) :572-81.|[2]Fang Zhao, et al. Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain. Toxins (Basel) . 2019 Apr 18;11 (4) :229.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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