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CD22 Polyclonal Antibody

CAT: 0763-D-AB-10188L-01Size: 25 µLDry Ice: NoHazardous: No
CAT#: D-AB-10188L-01Size: 25 µL
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.
Abbreviation
CD22
UniProt
P20273
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant Human CD22 protein expressed by E.coli
Target
B cell receptor CD22 precursor; B lymphocyte cell adhesion molecule; BL CAM; CD 22; CD22 antigen; CD22 molecule; Lectin 2; Leu14; Lyb8; MGC130020; sialic acid binding Ig like lectin 2; SIGLEC 2; T cell surface antigen Leu 14
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Immunology; Stem Cells
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:200-1:400
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
95kDa
Observed Molecular Weight
135kDa
Isotype
IgG

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