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Barakol

CAT: 0804-HY-167825Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-167825Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin. Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects[1][2][3].
CAS Number
24506-68-1
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; MMP; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/barakol.html
Smiles
OC1=CC2=C3C(OC(C)=CC(OC(C)=C2)3O)=C1
Molecular Formula
C13H12O4
Molecular Weight
232.23
References & Citations
[1]Thongsaard W, et al. Barakol: a potential anxiolytic extracted from Cassia siamea. Pharmacol Biochem Behav. 1996 Mar;53 (3) :753-8. |[2]Wongsawatkul O, et al. Effects of barakol from Cassia siamea on neuroblastoma SH-SY5Y cell line: A potential combined therapy with doxorubicin. Heliyon. 2024 Jan 19;10 (3) :e24694. |[3]Wongtongtair S, et al. Barakol-induced apoptosis in P19 cells through generation of reactive oxygen species and activation of caspase-9. J Ethnopharmacol. 2011 Sep 2;137 (2) :971-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
TN8213-01Barakol

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