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Eflapegrastim

CAT: 0804-HY-P99913Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P99913Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eflapegrastim is a composite protein consisting of a genetically modified granulocyte-colony stimulating factor (GCSF) molecule linked via a chemical bond to an IgG4 Fc fragment (LAPS-carrier) . Eflapegrastim targets to G-CSF receptor (c-Fms) . Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia[1].
CAS Number
1384099-30-2
UNSPSC
12352203
Target
C-Fms
Type
Inhibitory Antibodies
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/eflapegrastim.html
Solubility
10 mM in DMSO
Smiles
[Eflapegrastim]
References & Citations
[1]Barrett JA, et al. Eflapegrastim's enhancement of efficacy compared with pegfilgrastim in neutropenic rats supports potential for same-day dosing. Exp Hematol. 2020 Dec;92:51-61.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched

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