HIF-2α-IN-1

HIF-2α-IN-1

• CAS Number: 1799948-06-3
• UNSPSC Description: HIF-2α-IN-1 is a HIF-2α inhibitor with an IC50 value of less than 500 nM.
• Target Antigen: HIF/HIF Prolyl-Hydroxylase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/HIF-2_alpha_-IN-1.html
• Purity: 99.92
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: N#CC1=CC(F)=CC(OC2=CC=C3C([C@@H](O)C(F)(F)S3(=O)=O)=C2C(F)F)=C1
• Molecular Weight: 405.30
• References & Citations: [1]Bruick Richard Keith, et al. HIF-2α inhibitors for treating iron overload disorders. From PCT Int. Appl. (2016), WO 2016057242 A1 20160414.|[2]Dixon Darryl David, et al. Preparation of cyclic sulfone and sulfoximine analogs as HIF-2α inhibitors. From PCT Int. Appl. (2015), WO 2015095048 A1 20150625.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported