Smurf1-IN-1

Smurf1-IN-1

• CAS Number: 1824708-03-3
• UNSPSC Description: Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1].
• Target Antigen: E1/E2/E3 Enzyme
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/smurf1-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=C(C)N(C2=CC=C(C3CC3)C=C2Cl)N=N1)NC4=C(C)N(C)N(C5CCCCC5)C4=O
• Molecular Weight: 468.98
• References & Citations: [1]Shaw DE, et.al. Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension. J Med Chem. 2023 Jun 22;66(12):8130-8139.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported