Etofylline

CAT: 0804-HY-B1209-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1209-01Size:500 mg
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Description
Etofylline (7- (β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos[1][2][3].
CAS Number
[519-37-9]
Product Name Alternative
7- (β-Hydroxyethyl) theophylline
UNSPSC
12352005
Hazard Statement
H302
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Etofylline.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N1C)N(C)C2=C(N(CCO)C=N2)C1=O
Molecular Formula
C9H12N4O3
Molecular Weight
224.22
Precautions
H302
References & Citations
[1]Wattanaporn Tavipatana, et al.Etophylline and theophylline pharmacokinetics when administered concomitantly in rabbits. International Journal of Pharmaceutics. Volume 30, Issues 2–3|[2]Chandrakantsing V Pardeshi , et al. Mannose-anchored N, N, N-trimethyl chitosan nanoparticles for pulmonary administration of etofylline. Int J Biol Macromol. 2020 Dec 15;165 (Pt A) :445-459.|[3]Ram Manohar Basnet, et al. Zebrafish Embryo as an In Vivo Model for Behavioral and Pharmacological Characterization of Methylxanthine Drugs. Int J Mol Sci. 2017 Mar 9;18 (3) :596.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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