AZD-9574

AZD-9574

• CAS Number: 2756333-39-6
• UNSPSC Description: AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 acts by selectively inhibiting and trapping PARP1 at the sites of SSBs. AZD-9574 is an anti-cancer agent and can be used for HRD+?breast cancer and advanced solid malignancies research[1].
• Target Antigen: PPAR
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/azd-9574.html
• Smiles: O=C(C1=NC(F)=C(N2CCN(CC2)CC3=C(F)C4=C(N=C(C)C(N4)=O)C=C3)C=C1)NC
• Molecular Weight: 428.44
• References & Citations: [1]Hybrid meeting divulges structures of drug candidates |[2]1.Kunzah Jamal, et al. Abstract 2609: AZD9574 is a novel, brain penetrant PARP-1 selective inhibitor with activity in an orthotopic, intracranial xenograft model with aberrant DNA repair. Cancer Res (2022) 82 (12_Supplement): 2609.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 2