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GW284543

CAT: 0804-HY-114189-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114189-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].
CAS Number
790186-68-4
Product Name Alternative
UNC10225170
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gw284543.html
Purity
99.94
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC
Molecular Formula
C23H20N2O3
Molecular Weight
372.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34 (5) :807-822.e7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK5

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