Ankyrin R Antibody
CAT:
400-SMC-487D
Size:
100 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Ankyrin R Antibody
- Background: Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. Ankyrin R, or Ank1, was first discovered in erythrocyres, but has since also been located in the brain and muscles. Mutations are associated with hereditary spehrocytosis and alzheimer's diease (2).
- Description: Mouse Anti-Human Ankyrin R Monoclonal IgG2B
- Specifications: Detects ~200kDa. Does not cross-react with Ankyrin-B or Ankyrin-G.
- Product Name Alternative: Ankyrin-R Antibody, Ankyrin-1 Antibody, Erythrocyte Ankyrin Antibody, ANK-1 Antibody, ANK Antibody, rCG_43073 Antibody
- Synonyms: Ankyrin R Antibody, Clone N388A/10
- CAS Number: 9007-83-4
- UNSPSC: 12352203
- Gene ID: 286
- Swiss Prot: P16157
- Accession Number: NP_000028.3
- Cellular Locus: Cytoplasm | Cytoskeleton | Myofibril | Sarcomere | M line
- Host: Mouse
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R
- Target: Ankyrin R
- Clonality: Monoclonal
- Isotype: IgG2B
- Clone: N388A/10 (Formerly sold as S388A-10)
- Conjugation: Unconjugated
- Validated Applications: WB, IHC, ICC/IF
- Purification: Protein G Purified
- Limit Of Detection: A 1:100 dilution of SMC-487 was sufficient for detection of Ankyrin R in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Concentration: 1 mg/ml
- Dilution: WB (1:1000); optimal dilutions for assays should be determined by the user.
- Weight: 0.1
- Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer changes when conjugated
- Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- References & Citations: 1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92. 2. Genes and mapped phenotypes. (n.d.). Retrieved April 21, 2015, from http://www.ncbi.nlm.nih.gov/gene/286