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WP1066

CAT: 0804-HY-15312-05Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15312-05Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.
CAS Number
857064-38-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; JAK; STAT
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WP1066.html
Purity
99.77
Solubility
DMSO : ≥ 44 mg/mL|Ethanol : 16.67 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=NC(Br)=CC=C2
Molecular Formula
C17H14BrN3O
Molecular Weight
356.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Verstovsek S, et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res, 2008, (3), 788-796.|[2]Hatiboglu MA, et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of WP1066 in murine melanoma models. Int J Cancer, 2012, 131 (1), 8-17|[3]Ferrajoli A, et al. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res, 2007, 67 (23), 11291-11299.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
JAK2; STAT3

Chemical Information

WP-1066

WP1066 is an organic molecular entity. It has a role as a STAT3 inhibitor.

CAS Number857064-38-1
PubChem CID11210478
IUPAC Name(E)-3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
Molecular FormulaC17H14BrN3O
Molecular Weight356.2
XLogP3.4
Topological Polar Surface Area65.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity462
SMILES
C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
InChI
InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
InChIKey
VFUAJMPDXIRPKO-LQELWAHVSA-N
Chemical Structure
2D Structure
2D structure of WP-1066
CAS: 857064-38-1
CID: 11210478
Formula: C17H14BrN3O
MW: 356.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight356.2
XLogP33.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass355.03202
Monoisotopic Mass355.03202
Topological Polar Surface Area65.8 Ų
Heavy Atom Count22
Formal Charge0
Complexity462
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A4140-SWP1066

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