GluA1 Antibody, Clone N355/1

• Background:

  GluR1, also known as glutamate receptor 1 or GRIA1, is an integral membrane protein and a subunit of AMPA-type ionotropic glutamate receptors. These receptors mediate fast excitatory neurotransmission in the central nervous system and are essential for synaptic plasticity, learning, and memory. GluR1 is widely expressed in the human brain and plays a central role in postsynaptic responses to glutamate—the primary excitatory neurotransmitter in mammals. While originally associated with kainate binding, GluR1 is now recognized as a core component of AMPA receptors, which are activated by glutamate and modulated by auxiliary proteins. Dysregulation of GluR1 expression, trafficking, or phosphorylation has been implicated in several neurodegenerative and neuropsychiatric disorders, including Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and schizophrenia. Aberrant GluR1 signaling can lead to excitotoxicity, synaptic dysfunction, and neuronal loss—hallmarks of neurodegeneration. Given its critical role in maintaining synaptic integrity and plasticity, GluR1 is a valuable target for therapeutic intervention and a potential biomarker for disease progression in neurodegenerative research.

• Description:

  Mouse Anti-Rat GluA1 (Glutamate Receptor 1) Monoclonal IgG1

• Specifications:

  Detects ~100kDa. Does not cross-react with GluR2.

• Product Name Alternative:

  2900051M01Rik, AI853806, AMPA 1, AMPA selective glutamate receptor 1, GLUH 1, GLUH1, GLUR1, GLURA, Glr-1, Glr1, GluA1, GluR K1, GluR-A, GluR1, GluRA, GluRK1, Glur-1, Glur1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Gria 1, HBGR1, HIPA, MGC13325, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, gluR-

• Synonyms:

  GluA1/GluR1 Antibody, Clone N355/1

• UNSPSC:

  12352203

• UN Code:

  Non-hazardous

• Hazard Statement:

  Non-hazardous

• Gene ID:

  50592

• Swiss Prot:

  P19490

• Accession Number:

  NP_113796

• Cellular Locus:

  Cell Membrane | Endoplasmic Reticulum | Cell Junction

• Host:

  Mouse

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1

• Target:

  GluR1

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Clone:

  N355/1

• Conjugation:

  Unconjugated

• Type:

  Monoclonal

• Applications:

  WB | IHC | ICC/IF

• Validated Applications:

  WB, IHC, ICC/IF

• Field of Research:

  Neuroscience | Neurotransmitter Receptors | (Glutamate Receptor 1) s | AMPA Receptors | Cell Signaling

• Purification:

  Protein G Purified

• Limit Of Detection:

  1 µg/ml of SMC-440 was sufficient for detection of GluA1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

• Concentration:

  1 mg/ml

• Dilution:

  WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

• Weight:

  0.1

• Buffer:

  PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer changes when conjugated

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2(4): 211-218. 2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88(17): 7557-7561. 3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.

• Shipping Conditions:

  Blue Ice or 4ºC

• Storage Conditions:

  -20ºC

• Specificity:

  Detects ~100kDa. Does not cross-react with GluR2.

• Background Reference 01:

  1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2 (4) : 211-218. 2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88 (17) : 7557-7561. 3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.

• Species:

  Human | Mouse | Rat

• CAS Number:

  9007-83-4

• Location:

  Cell Membrane | Endoplasmic Reticulum | Cell Junction

• Isotype:

  IgG1

• Immunogen Species:

  Rat