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GluA1 Antibody, Clone N355/1

CAT: 0400-SMC-440DSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0400-SMC-440DSize:100 µg
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Background
GluR1, also known as glutamate receptor 1 or GRIA1, is an integral membrane protein and a subunit of AMPA-type ionotropic glutamate receptors. These receptors mediate fast excitatory neurotransmission in the central nervous system and are essential for synaptic plasticity, learning, and memory. GluR1 is widely expressed in the human brain and plays a central role in postsynaptic responses to glutamate—the primary excitatory neurotransmitter in mammals. While originally associated with kainate binding, GluR1 is now recognized as a core component of AMPA receptors, which are activated by glutamate and modulated by auxiliary proteins. Dysregulation of GluR1 expression, trafficking, or phosphorylation has been implicated in several neurodegenerative and neuropsychiatric disorders, including Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and schizophrenia. Aberrant GluR1 signaling can lead to excitotoxicity, synaptic dysfunction, and neuronal loss—hallmarks of neurodegeneration. Given its critical role in maintaining synaptic integrity and plasticity, GluR1 is a valuable target for therapeutic intervention and a potential biomarker for disease progression in neurodegenerative research.
Description
Mouse Anti-Rat GluA1 (Glutamate Receptor 1) Monoclonal IgG1
CAS Number
9007-83-4
Specifications
Detects ~100kDa. Does not cross-react with GluR2.
Product Name Alternative
2900051M01Rik, AI853806, AMPA 1, AMPA selective glutamate receptor 1, GLUH 1, GLUH1, GLUR1, GLURA, Glr-1, Glr1, GluA1, GluR K1, GluR-A, GluR1, GluRA, GluRK1, Glur-1, Glur1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Gria 1, HBGR1, HIPA, MGC13325, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, gluR-
Synonyms
GluA1/GluR1 Antibody, Clone N355/1
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
50592
Swiss Prot
P19490
Accession Number
NP_113796
Cellular Locus
Cell Membrane | Endoplasmic Reticulum | Cell Junction
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1
Target
GluR1
Clonality
Monoclonal
Isotype
IgG1
Clone
N355/1
Conjugation
Unconjugated
Type
Monoclonal
Applications
WB | IHC | ICC/IF
Validated Applications
WB, IHC, ICC/IF
Field of Research
Neuroscience | Neurotransmitter Receptors | (Glutamate Receptor 1) s | AMPA Receptors | Cell Signaling
Purification
Protein G Purified
Limit Of Detection
1 µg/ml of SMC-440 was sufficient for detection of GluA1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2(4): 211-218. 2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88(17): 7557-7561. 3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~100kDa. Does not cross-react with GluR2.
Background Reference 01
1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2 (4) : 211-218. 2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88 (17) : 7557-7561. 3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.
Species
Human | Mouse | Rat
Location
Cell Membrane | Endoplasmic Reticulum | Cell Junction
Isotype
IgG1
Immunogen Species
Rat

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