Alpha-2C Adrenergic Receptor Antibody

• Background:

  The alpha 2C Adrenergic Receptor controls the release of neurotransmitter from central adrenergic neurons and from sympathetic nerves in the heart. This receptor also plays a role in cognitive and behavioral function. Two variants are produced by alternative splicing. Alpha 2C Adrenergic Receptor has been reported extensively in the brain. Blood, corpus cavermosum, kidney, and heart tissues have also been reported to express the protein.

• Description:

  Mouse Anti-Human Alpha-2C Adrenergic Receptor Monoclonal IgG1

• Specifications:

  Detects 50kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.

• Product Name Alternative:

  Adra 2c Antibody, Alpha-2CAR Antibody, ADRA2C Antibody, ADRA2L2 Antibody, ADRARL2 Antibody, Alpha 2CAR Antibody, alpha2 AR C4 Antibody, alpha2 C4 Antibody, alpha2C Antibody, ALPHA2CAR Antibody, Alpha-2 adrenergic receptor subtype C4 Antibody, Alpha-2C adrenoreceptor Antibody, Adrenergic alpha 2C receptor Antibody, Alpha 2C adrenergic receptor Antibody, Alpha 2C adrenergic receptor subtype C4 Antibody, Alpha 2C adrenoceptor Antibody, Alpha 2C adrenoreceptor Antibody, Alpha-2-adrenergic receptor Antibody, renal type Antibody, alpha2cii-adrenergic receptor Antibody, Subtype alpha2 C4 Antibody

• Synonyms:

  Alpha2C Adrenergic Antibody, Clone N330A/80

• UNSPSC:

  12352203

• Gene ID:

  152

• Swiss Prot:

  P18825

• Accession Number:

  NP_000674.2

• Cellular Locus:

  Cell Membrane

• Host:

  Mouse

• Species Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide amino acids 442- 462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor

• Target:

  Alpha2C Adrenergic

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Clone:

  N330A/80 (Formerly sold as S330A-80)

• Conjugation:

  Unconjugated

• Validated Applications:

  WB, ICC/IF

• Purification:

  Protein G Purified

• Limit Of Detection:

  1 µg/ml of SMC-435 was sufficient for detection of Alpha2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha- lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

• Concentration:

  1 mg/ml

• Dilution:

  WB (1:1000); optimal dilutions for assays should be determined by the user.

• Weight:

  0.012

• Buffer:

  PBS pH7.4, 50% glycerol, 0.09% sodium azide

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Filipeanu C.M., et al. (2011) Biochim Biophys Acta. 1813: 346-357. 2. Powe D.G., et al. (2011) Breast Cancer Res Treat. 130: 457-463.

• CAS Number:

  9007-83-4