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MGluR1/5 Antibody, Clone N75/3

CAT: 0400-SMC-419SSize: 12 µgDry Ice: NoHazardous: No
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CAT#:0400-SMC-419SSize:12 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MGluR5 (metabotropic glutamate receptor 5) is a subtype of glutamate receptor that regulates synaptic transmission and plasticity via G-protein-coupled signaling. It is predominantly expressed in the hippocampus, cortex, and striatum—regions vulnerable to neurodegeneration. Aberrant mGluR5 activity has been linked to excitotoxicity, calcium dysregulation, and neuroinflammation, contributing to the pathophysiology of Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) . mGluR5 also interacts with amyloid precursor protein and tau, influencing their aggregation and toxicity. Pharmacological modulation of mGluR5 has shown promise in preclinical models, where antagonists reduce neuronal loss and improve cognitive outcomes. As a key regulator of glutamatergic tone, mGluR5 is a compelling target for therapeutic intervention in neurodegenerative disorders characterized by synaptic dysfunction and excitatory imbalance.
Description
Mouse Anti-Rat mGluR1/5 glutamate receptor Monoclonal IgG2A
CAS Number
9007-83-4
Specifications
Detects ~130kDa (both mGluR1 and mGluR5).
Product Name Alternative
MGluR5, mGlu5, GRM5, GPRC1E, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, Glutamate receptor metabotropic 5, mGluR5a, mGluR5b, mGluR, Glutamate receptor metabotropic 1, mGlu1, mGluR1, GRM1, GRM 1, GRM1A, GRM1 alpha, GRM1_HUMAN, GPRC1A, Metabotropic glutamate receptor 1, mGluR1 alpha
Synonyms
mGluR1/5 Antibody, Clone N75/33
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
24418
Swiss Prot
P31424
Accession Number
NP_058708.1
Cellular Locus
Cell Membrane
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
Target
mGluR5
Clonality
Monoclonal
Isotype
IgG2A
Clone
N75/3 (Formerly sold as S75-3)
Conjugation
Unconjugated
Type
Monoclonal
Applications
WB | IHC | ICC/IF | IP
Validated Applications
WB, IHC, ICC/IF, IP
Field of Research
Neuroscience | Neurotransmitter Receptors | Glutamate Receptors | Metabotropic Glutamate Receptors (mGluR) | Cell Signaling | Cancer
Purification
Protein G Purified
Limit Of Detection
1 µg/ml of SMC-419 was sufficient for detection of mGluR1/5 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:1000), ICC/IF (1:1000) ; optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Mayer M.L. (2005) Current Opinion in Neurobio. 15(3): 282-288. 2. Keinane K., et al. (1990) Science. 249: 556-560.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~130kDa (both mGluR1 and mGluR5) .
Background Reference 01
1. Mayer M.L. (2005) Current Opinion in Neurobio. 15 (3) : 282-288. 2. Keinane K., et al. (1990) Science. 249: 556-560.
Species
Human | Mouse | Rat
Location
Cell Membrane
Isotype
IgG2A
Immunogen Species
Rat

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