GABA-A Receptor Delta Antibody

• Background:

  The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2).

• Description:

  Mouse Anti-Rat GABA-A Receptor Delta Monoclonal IgG2a

• Specifications:

  Detects ~55kDa.

• Product Name Alternative:

  GABAA-RD Antibody, Gabrd Antibody, MGC105467 Antibody

• Synonyms:

  GABA A Receptor Delta Antibody, Clone N151/3

• UNSPSC:

  12352203

• Gene ID:

  29689

• Swiss Prot:

  P18506

• Accession Number:

  NP_058985.1

• Cellular Locus:

  Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane

• Host:

  Mouse

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide amino acids 15-34 (N-terminus) of rat GABA-A-R-Delta

• Target:

  GABA A Receptor

• Clonality:

  Monoclonal

• Isotype:

  IgG2a

• Clone:

  N151/3 (Formerly sold as S151-3)

• Conjugation:

  Unconjugated

• Validated Applications:

  WB, ICC/IF, AM

• Purification:

  Protein G Purified

• Limit Of Detection:

  2 µg/ml of SMC-345 was sufficient for detection of Delta1 GABA-A receptor in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

• Concentration:

  1 mg/ml

• Dilution:

  WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

• Weight:

  0.1

• Buffer:

  PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.

• CAS Number:

  9007-83-4